GDF-15, also entitled macrophage inhibitory cytokine-1 (MIC-1) is a cytokine expressed in many tissues, including myocardium, lung, kidney, brain, liver, and the intestine, upon various stimuli, including myocardial stretch, volume overload, experimental cardiomyopathy and oxidative stress, other inflammatory cytokines, and ischemia/reperfusion (for a detailed overview see [18]). This evidence concerns the gene GDF15 and cardiomyopathy.