In particular, we previously demonstrated that CD133+ SK-N-DZ NB cells are enriched in CSCs as assessed by gene expression analysis and orthotopic xenotransplantation in immunodeficient mice [23,41,42] Although not specific of NB CSCs, CD133 is thus currently the best available surface marker associated with NB stem cell-like phenotype. The gene discussed is PROM1; the disease is neuroblastoma.