Recent studies have shown that IFN-I responses involving pathways mediated by cytosolic DNA and RNA sensors/adaptors such as STING (Stimulator of interferon genes), MDA5 (Melanoma differentiation-associated protein 5), and MAVS (Mitochondrial antiviral-signaling protein) can suppress early parasitemia and control liver stage development [7–10], although the mechanism of the IFN-I response in malaria control and pathology is far from clear. Here, IFIH1 is linked to parasitic infectious disease.