Among PtdIns(3,4,5)P3 phosphatases, PTEN (phosphatase and tensin homologue deleted on chromosome 10) has long been identified as a haploinsufficient tumor suppressor gene and negative regulator of the insulin signaling via PI3K/AKT signaling by dephosphorylating PIP3 [53, 54]. This evidence concerns the gene PIK3CA and neoplasm.