Several techniques have been reported to address this task, including the use of magnetic resonance spectroscopy (MRS) to detect 2-hydroxyglutarate (2-HG) as a metabolic product of IDH1/2 mutation [5–7] or the use of 11C-methionine positron emission tomography for detection of 1p/19q co-deletion in WHO grade 2 and 3 gliomas [19]. Here, IDH1 is linked to central nervous system cancer.