Although the mechanisms responsible for the decrease of circulating VEGF receptors upon small molecule inhibition are not fully understood, our results are entirely in line with previous observations made with nintedanib in solid tumors [31] and with other kinase inhibitors targeting VEGFR-2 such as cediranib [32] or AG-01736 [33] in AML. The gene discussed is KDR; the disease is acute myeloid leukemia.