CREB1 and central nervous system cancer: Our result may be inconsistent with results by Choi et al (2012) study, in which fluoxetine regulated neuronal plasticity and neurite outgrowth by phosphorylating and activating cAMP response element-binding protein (CREB) via NCAM-induced activation of MAPK pathway, probably because they used differentiated neuron-like cells from glioma cell line.