To determine the potential role of glucose and glutamine in the HBP and GlcNAcylation in DLBCL cells, we investigated whether depriving DLBCL cells of glucose, glutamine, or both would affect GlcNAc, NF-κB-p65, NFATc1 levels, and influence cell growth/survival outcomes. The gene discussed is NFATC1; the disease is diffuse large B-cell lymphoma.