To determine the biological significance of the HBP and O-GlcNAcylation for the growth and survival of DLBCL, OGT expression in three representative DLBCL cell lines with high levels of OGT and GlcNAC (OCI-LY10, MS, EJ) and one DLBCL cell line with low levels of OGT and GlcNAC (CJ) was knocked down using a validated small interference RNA (siRNA) approach (Supplementary Figure S2). Here, OGT is linked to diffuse large B-cell lymphoma.