More data, including direct quantification of the in vivo CD25+CD4+FOXP3+ Treg population and evaluation of the effects of immunoblocking with specific CCL28 antibodies on the in vivo tumor growth, are required to obtain from the mouse hepatic tumor model generated in this study, and will convincingly establish the repressive role of Treg cells in maintaining antitumor immunoresponse during liver tumorigenesis. This evidence concerns the gene CD4 and neoplasm.