In the present study, we found the reduction in Met expression by Ran knockdown was not diminished by ZVAD and MG132 treatment in both breast (MDA MB231; Figure 5B, left panel) and lung (A549; Figure 5B, right panel) cancer cell lines, indicating that caspase and proteasome degradation were not involved in the reduction in levels of Met by Ran In contrast, we found that treatment with GM6001, a metalloproteinase inhibitor, counteracted the downregulation of Met levels upon Ran knockdown in both MDA MB231 (Figure 5C, left panel) and A549 (Figure 5C, right panel) cancer cells. The gene discussed is RAN; the disease is cancer.