Univariate and multivariate Cox proportional hazards model analyses of overall survival including p16 expression, N-category, T-category, vascular invasion (V), tumor site, PITX2 hypermethylation, and PANCR hypermethylation. For dichotomization of PITX2 and PANCR DNA methylation, the optimized cut-off was used. The gene discussed is CDKN2A; the disease is neoplasm.