Moreover, the SHIP2 encoding gene was again significantly increased in colorectal carcinoma compared to healthy colon in the studies by Kaiser et al. and Skrzypczakand and co-workers (n = 41 versus n = 5, and n=10 versus n = 5 respectively) [25, 26] (Figure 1A–1C). Here, INPPL1 is linked to colorectal carcinoma.