Recently a composite urinary biomarker activity index was reported based upon the urinary levels of six proteins, including adiponectin, NGAL, MCP-1, KIM-1, ceruloplasmin, and hemopexin, that can differentiate pediatric LN patients with high activity indices on renal biopsy from those with low or moderate activity indices with >92 % accuracy [48]. The gene discussed is HAVCR1; the disease is lobular neoplasia.