PRTN3 and rheumatoid arthritis: Interestingly, as shown in Fig. 2b, the I473T variant is highly associated with erosive disease in ACPA-positive patients with RA (p = 0.017 in the total cohort and p = 0.0049 in female patients) and with a lower response to infliximab treatment as measured by the change in DAS28 score (p = 0.012 in the total cohort) as well as by the European League Against Rheumatism response criteria (p = 0.025 in the total cohort), which indicate that this variant is represented in a group of patients with more severe disease.