Synaptotagmin-1 (215–223) correlated with amyloid-β1-42 in the control group (rho = 0.515, P = 0.04 and rho = 0.381, P = 0.02, respectively), but not in patients with either MCI due to Alzheimer’s disease or dementia due to Alzheimer’s disease (Table 2). Here, SYT1 is linked to early-onset autosomal dominant Alzheimer disease.