INS and Glucose intolerance: As previously observed [11], the strain carrying the largest GK haplotype (179.3 Mb in BN.GK1cns) exhibited increased body weight (270.0 ± 5.7 versus 243.4 ± 3.5) and adiposity (0.416 ± 0.028 versus 0.376 ± 0.031), glucose intolerance (CumG, 5504 ± 135 versus 5104 ± 83) and enhanced glucose-induced insulin secretion (CumI, 70.21 ± 11.50 versus 43.45 ± 3.23).