TLR2 and infection: These results indicate an increased susceptibility of TLR2−/− mice to infection with both species, with higher average parasite burdens at all time points p.i. after lesion appearance, significantly so at 12 weeks p.i. (Mann-Whitney U = 1, P = 0.0023) with L. major (Fig. 2b), and 14 weeks p.i. after infection with both L. mexicana promastigotes (U = 4, P = 0.019) and amastigotes (U = 8, P = 0.021) (Fig. 2d, e).