Although the protective influence of TLR2 was consistently observed in our experiments for both L. major and L. mexicana, other studies using the species L. braziliensis and L. donovani, have demonstrated an exacerbatory role for TLR2 during infection [25, 26, 45], illustrating the influence of TLR2 is complex and can exert profoundly different species-dependent outcomes. The gene discussed is TLR2; the disease is infection.