In this study, mice lacking TLR2, TLR1, TLR6 and TLR4, were infected with L. major or L. mexicana to determine the role of TLR2 and its known co-receptors in cutaneous leishmaniasis in vivo, and to compare these to TLR4, which has previously been reported to facilitate the control of L. major infection. The gene discussed is TLR4; the disease is cutaneous leishmaniasis.