TP53 and cancer: Liu et al. [51], for example, demonstrated in patients with nonsmall-cell lung cancer that known functional germline polymorphisms in EGFR predict both higher somatic mutational burden and also specific somatic exonic microdeletions within EGFR. Additionally, Rausch et al. [52] found that chromothripsis (the occurrence of massive somatic chromosomal rearrangements within localized regions of the genome) in some, but not all, cancers, was associated with the presence of high-penetrance germline mutations in TP53 that have been associated with LFS.