PALB2 and breast cancer: More recently, Antoniou et al. [20] examined the breast cancer risk in 362 members of 154 families with loss of function mutations in PALB2. They found an age-dependent trend in breast cancer risk among PALB2 mutation carriers relative to age-matched controls (age 40–44 years, RR = 8.02; age 50–54, RR = 6.55; age 60–64, RR = 5.45).