The impact of mutations in either gene can be dramatic; 65 % and 45 % of women with deleterious mutations in BRCA1 or BRCA2, respectively, will develop breast cancer by age 70 [13], and the risk increases to 85 % and 84 %, respectively, for women with a family history of breast cancer [14, 15]. The gene discussed is BRCA1; the disease is breast carcinoma.