While no direct evidence relate KCNE3 or KCNE4 to glioblastoma, KCNE4 is most abundantly expressed in brain [68]; it exerts functions such as controlling the neuronal firing rate, the synaptic transmission [69] and the T-lymphocytes maturation [70] and it is known to regulate K-channels in vascular smooth muscle [71] and more in general neuronal excitability. This evidence concerns the gene KCNE4 and glioblastoma.