To further explain why neuronal A20 upregulation reduced focal cerebral ischemia/reperfusion-induced inflammatory injury, correlation analysis revealed that the number of A20-expressing neurons in the ischemia/reperfusion cortex was significantly positively correlated with neurological function score but negatively correlated with the cerebral infarction volume, glial cell activation, and pro-inflammatory cytokine content in the brain. Here, TNFAIP3 is linked to cerebral infarction.