BCHE and metastatic neoplasm: Patients with more than 3 concomitant diseases and the presence of at least one of four cancer related risk factors (metastatic disease, high-grade biology, biochemical markers for pre-cachexia, such as CRP <1 and/or lowered serum Cholin Esterase activity; high-risk) were compared to patients with either less than 3 concomitant diseases or more than 3 concomitant diseases but no cancer related risk factors (low-risk).