TGFB1 and Buschke-Ollendorff syndrome: In particular, BOS is responsible for both protein (p < 0.01) and mRNA (p < 0.05) decreases of α-SMA, protein (p < 0.01) and mRNA (p < 0.05) decreases of Col I, and protein (p < 0.01) and mRNA (p < 0.05) decreases of TGF-β.