In particular, BOS is responsible for both protein (p < 0.01) and mRNA (p < 0.05) decreases of α-SMA, protein (p < 0.01) and mRNA (p < 0.05) decreases of Col I, and protein (p < 0.01) and mRNA (p < 0.05) decreases of TGF-β. The gene discussed is ACTA1; the disease is Buschke-Ollendorff syndrome.