Thus, in the present study, we assessed the associations between circulating betatrophin levels and cardiometabolic risk factors including obesity, high blood pressure, dyslipidemia, IR, hyperglycemia and test whether these associations are affected by vitamin D conditions in a cohort of Chinese youth at risk for metabolic syndrome (MS). This evidence concerns the gene ANGPTL8 and obesity due to melanocortin 4 receptor deficiency.