Hepatic GNMT is reported elevated in streptozotocin-treated rats [20], a missense mutation (fatty, fa) in the leptin receptor gene (ZFD) rats [21], and retinoic acid/dexamethasone-treated rats [22], suggesting that the regulatory mechanisms of GNMT in the liver differ between type 1 diabetes and T2DM, and between dietary and genetic models. Here, GNMT is linked to type 2 diabetes mellitus.