RAB25 and esophageal squamous cell carcinoma: For example, in addition to its role in increasing invasiveness of cancer cells, Rab25 has also been identified to act as a tumor suppressor by inhibiting invasive and angiogenic activities in esophageal squamous cell carcinoma [55] and by increasing malignant tumor formation in the intestines of Rab25-/-;ApcMin/- mice [56].