Indeed, a set of Rab proteins including Rab1, Rab2A, Rab3D, Rab8, Rab11, Rab21, Rab23, Rab25, Rab27B, Rab35 and others (as reviewed in Table 1) promotes tumor cell migration and invasion to exhibit their effects on tumorigenesis and metastasis by regulating intracellular signal transduction [39–49]. This evidence concerns the gene RAB27B and neoplasm.