Despite recent meta-analyses of randomized clinical trials including results of SAVOR-TIMI and EXAMINE suggested an increased risk of hospitalization due to HF in T2D patients [59–62], others have found no difference in hospitalization rates for HF between treatment with saxagliptin compared with sitagliptin or with DPP-4 inhibitors compared with other classes of anti-diabetes agents [63, 64]. This evidence concerns the gene DPP4 and diabetes mellitus.