AKT2 and ovarian carcinoma: Furthermore, Xia et al. found that p21WAF1/KIP1 translocation into the cytoplasm via constitutively active Akt2 transfection in ovarian cancer cells enhanced the resistance to paclitaxel, while inhibition of p21WAF1/KIP1 translocation into the cytoplasm via Akt2 shRNA transfection in ovarian cancer cells significantly increased paclitaxel treatment sensitivity.