The only other study of the association between serum bicarbonate and mortality exclusively in diabetes involved combined data from patients with CKD who participated in the Reduction of End points in Non-insulin-dependent diabetes with the Angiotensin II Antagonist Losartan (RENAAL) trial or the Irbesartan Diabetic Nephropathy Trial (IDNT) [10]. The gene discussed is AGT; the disease is diabetic kidney disease.