CXCL12 and serum lipopolysaccharide activity: In addition, by detecting effects with the CXCR4 antagonist, AMD3100, that are in direct contrast to those observed with the CXCL12 analog, CTCE-0214D, in endotoxemia, we can hypothesize that treatment with CTCE-0214D exerts its protective effects mainly via CXCR4.