In contrast to subjects in quartile 1 (8.42–8.70 mg/dL), there were significantly increased risk of HFpEF with subjects in quartile 4 [(9.23–10.42 mg/dL), OR (95 % CI) = 2.331 (1.088–4.994), p = 0.029], after adjusted for possible confounding factors including age, gender and obesity in model 1, further adjusted for smoking, hypertension, and dyslipidemia in model 2, and furthermore adjusted for LVMI, lg Alb/Cr, lg HOMA-IR and uric acid in model 3. The gene discussed is ALB; the disease is Hypertension.