Inhibition of EGFR using either monoclonal antibodies (mAbs) against the extracellular domain or small molecule G-protein coupled receptors (TKI) inhibitors against the intracellular domain [5], combining mAbs with radiotherapy [6] and chemotherapy [7], have resulted in therapeutic benefits [8] including improvement in tumor response and overall survival in cancers [9–12]. The gene discussed is EGFR; the disease is neoplasm.