On the other hand, these mediators and cytokines, in turn, might promote and enhance the abnormal cellular proliferation associated with polyp and bladder cancer, through generating various mediators, including inflammatory cytokines such as interleukin-6 (IL-6) and cellular growth factor (TGF-β) [23, 25, 26]. This evidence concerns the gene TGFB1 and urinary bladder cancer.