In contrast to IL-17A, global IL-17RA immunoreactivity was significantly elevated in cystitis and polyp compared with those of bladder cancer (Fig. 1c and d, p = 0.001 and p = 0.001, respectively), while global IL-17RA immunoreactivity was significantly higher in polyps than those of cystitis (p = 0.015). This evidence concerns the gene IL17A and chronic cystitis.