MAPK14 and early-onset autosomal dominant Alzheimer disease: In conclusion, though not all the pieces of the puzzle have been put in place, the work of Schnöder and colleagues indicates that inhibition of MAPK14 has the potential to be a pharmacological approach to mitigate defects in the autophagy-lysosomal system, which has been proposed as a critical component of the pathogenesis of Alzheimer disease.