After adjusting for the matching variables, OSSN was strongly associated with HIV infection (OR = 18.96, 95% CI: 8.87–40.5), lower CD4 count (OR = 37.33, 95% CI: 7.98–174.5 for CD4 < 200 cells/mm3 compared with CD4 > 500 cells/mm3) and history of allergic conjunctivitis (OR = 30.78, 95% CI: 4.05–234). Here, CD4 is linked to HIV infectious disease.