The longevity factor klotho is a pleiotropic protein that suppresses aging (Kuro-o et al. 1997; Kurosu et al. 2005), enhances cognitive functions (Dubal et al. 2015; Dubal et al. 2014; Yokoyama et al. 2015), and promotes resilience against pathogenic proteins related to AD (Dubal et al. 2015; Zeldich et al. 2014). This evidence concerns the gene KL and Alzheimer disease.