CCN1 and breast carcinoma: Although it remains to be determined whether FASN-driven lipogenesis might directly participate in the increased neovascularization that we previously reported in tumors formed by HRG- and CCN1-overexpressing breast cancer cells, attenuation of FASN-dependent endogenous lipogenesis has been shown to abolish the establishment of metastatic colonies without significantly affecting the growth of the primary tumor [51].