That FASN expression becomes activated in response to high levels of the angiogenic inducer CCN1 together with the finding that the status of FASN expression parallels CCN1-regulated secretion of the archetypical angiogenic factor VEGF165 might counterintuitively suggest that FASN signaling plays an active role in CCN1-driven breast cancer angiogenesis, a crucial step for metastasis. This evidence concerns the gene FASN and breast carcinoma.