In pancreatic adenocarcinoma cells, EFEMP1 activates AKT signaling in pancreatic carcinoma cell lines [30], and activates NF-κB signaling to promotes the migration and invasion of osteosarcoma via MMP-2 with induction by AEG-1 [16]. The gene discussed is AKT1; the disease is exocrine pancreatic carcinoma.