The therapeutic effect of a protein product based on the sequence of the ESTP has been proven in a glioma animal model, as well as mechanistically, by its targeting of EGFR, NOTCH, MMP2 and pAKT) (manuscript in preparation, abstract ATPS-99 and poster shown at the 20th SNO Annual Scientific Meeting and Education Day, San Antonio, Nov. Here, MMP2 is linked to central nervous system cancer.