Proliferation in responses to lesion or tumor antigens by isolated CD4+ and CD8+ T cells from the cervical lymph nodes of indomethacin-treated vs. diluent control-treated mice would also provide insight into the mechanism of how inhibiting PGE2 production at the premalignant lesion stage impacts on the anti-lesion or antitumor response. This evidence concerns the gene CD8A and neoplasm.