In another study using colorectal cancer cells, TNFRSF19 was identified as target gene downstream of the Wnt/β-catenin pathway and TNFRSF19 ligands activated NF-κB signaling, thus revealing an indirect way by which β-catenin positively regulates NF-κB activity (57). This evidence concerns the gene NFKB1 and colorectal cancer.