Members of the IL-1 subfamily, such as IL-36α (IL-1F6), IL-36β (IL-1F8), IL-36γ (IL-1F9), IL-36R (IL-1Rrp2), and the receptor antagonist IL-36Ra (IL-1F5) constitute a novel signaling system that has not been studied in depth in the normal inflammatory process of pregnancy, or in pregnant women with a bacterial infection. Here, IL36A is linked to bacterial infectious disease.