For instance, germline mutations in genes encoding Cx26, Cx30, Cx31, Cx32 and Cx43 are linked with almost the half of all cases of inherited neurosensory deafness (Martínez et al., 2009), whereas Cx32 and Cx47 mutations are associated with X-linked Charcot–Marie–Tooth (Kleopa et al., 2006) and Pelizaeus–Merzbacher-like (Bugiani et al., 2006) diseases, respectively. The gene discussed is GJB1; the disease is sensorineural hearing loss disorder.