The quantification of six proteins (Table 1), acetylated platelet cyclooxygenase-1 (platelet Ac-COX-1) [3], serum apolipoprotein A1 (ApoA-I) [4], serum ApoC-III [5], serum C-reactive protein (CRP), serum high mobility group box-1 (HMGB1) [6], and serum insulin-like growth factor I (IGF-I) [7, 8], which are involved in various aspects of cardiovascular disease will be discussed in detail below. The gene discussed is HMGB1; the disease is cardiovascular disorder.