RUNX1T1 and acute myeloid leukemia: Approximately 12–15% of cases with adult acute myeloid leukemia (AML) carry the (8;21) translocation, which fuses the AML1 (also known as RUNX1) and ETO (otherwise RUNX1T1 or MTG8) genes and results in expression of the AML1/ETO chimeric protein1.