EEF1A2 and non-small cell lung carcinoma: Given the fact that eEF1A2 downregulation was the only major modification detected by both microarray and iTRAQ experiments, and to examine whether this was a general mechanism of plitidepsin resistance, we generated two additional plitidepsin-resistant cell lines from NCI-H460 (non-small cell lung cancer) and HGC27 (gastric carcinoma), as previously described for HeLa cells11.