Only DKO rats showed elevated PBG levels at 7 weeks (n = 8, p = 0.0008), but both Mc4r KO and DKO displayed hyperglycaemia by 13 weeks of age (Fig. 6c, n = 6, p = 0.02 for Mc4r KO, p = 0.002 for DKO). Here, MC4R is linked to Hyperglycemia.