CYP2E1 and endometrial cancer: This result points in the same hypothesized direction of acrylamide itself being the more relevant compound as the result for the other 2 SNPs because the variant allele of rs6413432 leads to increased CYP2E1 gene expression8 and the association between acrylamide and endometrial cancer risk was strongest in women homozygous for the wild type allele.