With 20.3 years of follow-up, there were some statistically significant interactions that were not observed with 11.3 years of follow-up: rs11252887 (AKR1C1) (only women with 1 or 2 variant alleles showed a clear increase in acrylamide-associated endometrial cancer risk), rs28362491 (NFKB1) (increased acrylamide-associated risk only in homozygous wild types), rs2228000 (XPC) (increased acrylamide-associated risk only in never-smoking homozygous wild types) and rs5275 (PTGS2) (increased acrylamide-associated risk only in homozygous wild types). The gene discussed is XPC; the disease is endometrial cancer.