First, to confirm the expression of GRP78 in glioma cell line in vivo, we injected cells of U-87 MG human glioblastoma multiforme (GBM) which accounts for 80% of all malignant brain cancer, into 5-week-old athymic mice and compared GRP78 expression in xenografted and normal brain tissue. This evidence concerns the gene HSPA5 and central nervous system cancer.