In the present study, we found that lung cancer risk-related loci (6p21 and 15q25) were also enriched in lncRNAs, such as RP11-650L12.2, HCP5, XXbac-BPG27H4.8, and HCG17. In this GWAS re-analysis study, we aimed to demonstrate the possibility that genetic variants in lncRNA regions might be associated with lung cancer development. This evidence concerns the gene HCP5 and lung cancer.