YAP1 and neoplasm: We first focused on the NF2–Hippo tumour suppressor network, which was highlighted by a series of reports showing that NF2 enforces the Hippo tumour suppression signalling pathway by phosphorylating, sequestering, degrading and suppressing YAP/TAZ nuclear translocation, thereby disrupting oncogenic transcription27, 28, 29, 30, 31, 32.