On the other hand, one tumour (T71) with FH G401V somatic mutation was found to be FH positive/2SC negative, and lacked histologic features of HLRCC or FH-deficient RCC40, 42, suggesting that FH G401V might be better categorized as a passenger mutation (Fig. 4a; Supplementary Fig. 5). This evidence concerns the gene FH and hereditary leiomyomatosis and renal cell cancer.