This effect, however, does not occur in patients with compensated cirrhosis or with ascites and normal plasma renin activity and norepinephrine indicating that increased renal synthesis of PGs in decompensated cirrhosis with ascites is a homeostatic response related to the activation of the endogenous vasoconstrictor system in order to maintain renal hemodynamics [35,36,37,38,39,40]. This evidence concerns the gene REN and Ascites.